Featured Publications

Bcl-XL inhibits membrane permeabilization by competing with Bax

Bcl-XL inhibits membrane permeabilization by competing with Bax

Billen L.P., Kokoski C.L., Lovell J.F., Leber, B., and Andrews, D.W., Bcl-XL inhibits membrane permeabilization by competing with Bax. (2008) PLoS Biol 6(6): e147. [Featured in a mini-review in the same issue and in Research Highlights, Nature Immunology, August 2008, 9:837; Faculty 1000 Biology: http://www.f1000biology.com/article/id/1123833/evaluation].

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Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

Aranovich, A., Liu, Q., Collins, T.J., Geng F., Dixit S., Leber B., and Andrews, D.W., Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. (2012) Mol Cell., 45:754-63.

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Mechanisms of action of Bcl-2 family proteins

Mechanisms of action of Bcl-2 family proteins

Shamas-Din A., Kale J., Leber B., and Andrews, D.W., Mechanisms of action of Bcl-2 family proteins. (2013) Cold Spring Harbor Perspectives In Biology, 5(4):a008714. (Review)

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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

Oppermann S., Ylanko J., Shi Y., Hariharan S., Oakes C.C., Brauer P.M., Zuniga-Pflucker J.C., Leber B., Spaner D.E., and Andrews, D.W., High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells. (2016) Blood. 128(7):934-947. doi: 10.1182/blood-2015-12-687814.

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A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

Niu X., Brahmbhatt H., Mergenthaler P., Zhang Z., Sang J., Daude M., Ehlert F.G.R., Diederich W.E., Wong E., Zhu W., Pogmore J.P, Nandy J.P., Satyanarayana M., Jimmidi R.K., Arya P., Leber B., Lin J., Culmsee C., Yi J., and Andrews, D.W., A small molecule inhibitor of both proapoptotic Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection.(2017) Cell Chemical Biology.24(4):493-506.e5. doi: 10.1016/j.chenbiol.2017.03.011.

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Shedding light on apoptosis at subcellular membranes

Shedding light on apoptosis at subcellular membranes

Andrews, D.W., Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins. Mitochondrial Dynamics and Physiology, Keystone Symposia on Molecular and Cellular Biology. Santa Fe, New Mexico, United States, February 19, 2014.

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