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A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

Niu X., Brahmbhatt H., Mergenthaler P., Zhang Z., Sang J., Daude M., Ehlert F.G.R., Diederich W.E., Wong E., Zhu W., Pogmore J.P, Nandy J.P., Satyanarayana M., Jimmidi R.K., Arya P., Leber B., Lin J., Culmsee C., Yi J., and Andrews, D.W., A small molecule inhibitor of both proapoptotic Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection.(2017) Cell Chemical Biology.24(4):493-506.e5. doi: 10.1016/j.chenbiol.2017.03.011.

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Shedding light on apoptosis at subcellular membranes

Shedding light on apoptosis at subcellular membranes

Andrews, D.W., Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins. Mitochondrial Dynamics and Physiology, Keystone Symposia on Molecular and Cellular Biology. Santa Fe, New Mexico, United States, February 19, 2014.

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BCL-2 family proteins: changing partners in the dance towards death

BCL-2 family proteins: changing partners in the dance towards death

Kale J., Osterlund E.J., and Andrews, D.W. BCL-2 family proteins: changing partners in the dance towards death. (2018) Cell Death Differ. 25(1):65-80. doi: 10.1038/cdd.2017.186. Review.

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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Kale J., Kutuk O., Costa Brito G., Andrews T., Leber B., Letai A., and Andrews D.W. Phosphorylation switches Bax from promoting to inhibiting apoptosis increasing drug resistance. (2018) EMBO Rep. 19(9):e45235. doi: 10.15252/embr.201745235.

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Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax Volume 135, Issue 6, 12 December 2008, Pages 1074-1084 Jonathan F.Lovell1Lieven P.Billen1ScottBindner1AishaShamas-Din1CecileFradin12BrianLeber13David W.Andrews

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Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

Leber, B., Kale, J., Andrews, D.W. Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove. (2018) Cancer Discovery. 8(12):1511-1514. doi: 10.1158/2159-8290.CD-18-1167.

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