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A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection X Niu, H Brahmbhatt, P Mergenthaler, Z Zhang, J Sang, M Daude, … Cell chemical biology 24 (4), 493-506. e5

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Shedding light on apoptosis at subcellular membranes

Shedding light on apoptosis at subcellular membranes

Shedding light on apoptosis at subcellular membranes J Kale, Q Liu, B Leber, DW Andrews Cell 151 (6), 1179-1184

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BCL-2 family proteins: changing partners in the dance towards death

BCL-2 family proteins: changing partners in the dance towards death

BCL-2 family proteins: changing partners in the dance towards death J Kale, EJ Osterlund, DW Andrews Cell death and differentiation 25 (1), 65

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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance J Kale, O Kutuk, GC Brito, TS Andrews, B Leber, A Letai, DW Andrews EMBO reports 19 (9), e45235

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Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax Volume 135, Issue 6, 12 December 2008, Pages 1074-1084 Jonathan F.Lovell1Lieven P.Billen1ScottBindner1AishaShamas-Din1CecileFradin12BrianLeber13David W.Andrews

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Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove B Leber, J Kale, DW Andrews Cancer discovery 8 (12), 1511-1514

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