"Researching precision cancer treatments, programmed cell death and the assembly of proteins into cellular membranes."

Using our custom microscopy, high-content screening and AI derived Image Analysis.

Precision Medicine

Historically cancer treatment has taken a ‘one size fits all’ approach. However, it’s clear that every patient’s cancer is different and being able to understand and accurately differences in drug response and efficacy of therapies may provide better treatment options. Using Chronic Lymphocytic Leukemia (CLL) and breast cancer as a disease models, we are developing […]

Programmed Cell Death

We are studying the mechanisms by which the Bcl-2 family of proteins regulates selective programmed cell death (apoptosis) of cancer cells. We are particularly interested in determining the molecular mechanisms by which Bcl-2 family proteins either inhibit or accelerate apoptosis.  The Bcl-2 family proteins that we study include those that initiate cell execution (Bax and […]

High Content Screening

One of our major goals is to use the fluorescence microscopy as a quantitative analytical tool.  An enormous advantage of microscopy is that it enables fluorescence measurements to be made in living cells.  To use fluorescence microscopy quantitatively we have developed new approaches, instruments and software.  Using fluorescence proteins and novel non-toxic dyes we image […]

Featured Publications

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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both...

Bcl-XL inhibits membrane permeabilization by competing with Bax

Bcl-XL inhibits membrane permeabilization by competing with Bax LP Billen, CL Kokoski,...

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2...

Mechanisms of action of Bcl-2 family proteins

Mechanisms of action of Bcl-2 family proteins A Shamas-Din, J Kale, B Leber, DW Andrews...

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

High-content screening identifies kinase inhibitors that overcome venetoclax resistance...

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection

A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death...

Shedding light on apoptosis at subcellular membranes

Shedding light on apoptosis at subcellular membranes J Kale, Q Liu, B Leber, DW Andrews...

BCL-2 family proteins: changing partners in the dance towards death

BCL-2 family proteins: changing partners in the dance towards death J Kale, EJ...

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing...

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane...