Featured Publications

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane

Lv F, Qi F, Zhang Z, Wen M, Piai A, Du L, Zhou L, Yang Y, Wu B, Liu Z, Rosario J, Pogmore JP, Chou JJ, Andrews DW, Jin J, Yang BO. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. EMBO Journal. 2021 Jun 8:e106438. doi: 10.15252/embj.2020106438.    

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Pharmacological Targeting of Executioner Proteins: Controlling Life and Death

Pharmacological Targeting of Executioner Proteins: Controlling Life and Death

Pogmore JP, Uehling D, Andrews DW. Pharmacological Targeting of Executioner Proteins: Controlling Life and Death. J Med Chem. 2021 May 13;64(9):5276-5290. doi: 10.1021/acs.jmedchem.0c02200.

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Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax. Mol Cell. 2020 Feb 20;77(4):901-912.e9. doi: 10.1016/j.molcel.2019.12.025.

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Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening

Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening

Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening  

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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Liu Q, Oesterlund EJ, Chi X, Pogmore J, Leber B, Andrews D.W., Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2. (2019). Elife. 8:e37689. doi: 10.7554/eLife.37689.

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Bcl-XL inhibits membrane permeabilization by competing with Bax

Bcl-XL inhibits membrane permeabilization by competing with Bax

Billen L.P., Kokoski C.L., Lovell J.F., Leber, B., and Andrews, D.W., Bcl-XL inhibits membrane permeabilization by competing with Bax. (2008) PLoS Biol 6(6): e147. [Featured in a mini-review in the same issue and in Research Highlights, Nature Immunology, August 2008, 9:837; Faculty 1000 Biology: http://www.f1000biology.com/article/id/1123833/evaluation].

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