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Featured Publications

Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening

Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening

Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening

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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 Q Liu, EJ Oesterlund, X Chi, J Pogmore, B Leber, DW Andrews eLife 8, e37689  

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Bcl-XL inhibits membrane permeabilization by competing with Bax

Bcl-XL inhibits membrane permeabilization by competing with Bax

Bcl-XL inhibits membrane permeabilization by competing with Bax LP Billen, CL Kokoski, JF Lovell, B Leber, DW Andrews PLoS biology 6 (6), e147

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Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells A Aranovich, Q Liu, T Collins, F Geng, S Dixit, B Leber, DW Andrews Molecular cell 45 (6), 754-763

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Mechanisms of action of Bcl-2 family proteins

Mechanisms of action of Bcl-2 family proteins

Mechanisms of action of Bcl-2 family proteins A Shamas-Din, J Kale, B Leber, DW Andrews Cold Spring Harbor perspectives in biology 5 (4), a008714

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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells S Oppermann, J Ylanko, Y Shi, S Hariharan, CC Oakes, PM Brauer, … Blood 128 (7), 934-947  

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