Mechanisms of action of Bcl-2 family proteins
Shamas-Din A., Kale J., Leber B., and Andrews, D.W., Mechanisms of action of Bcl-2 family proteins. (2013) Cold Spring Harbor Perspectives In Biology, 5(4):a008714. (Review)
Read MoreHigh-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells
Oppermann S., Ylanko J., Shi Y., Hariharan S., Oakes C.C., Brauer P.M., Zuniga-Pflucker J.C., Leber B., Spaner D.E., and Andrews, D.W., High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells. (2016) Blood. 128(7):934-947. doi: 10.1182/blood-2015-12-687814.
Read MoreA small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection
Niu X., Brahmbhatt H., Mergenthaler P., Zhang Z., Sang J., Daude M., Ehlert F.G.R., Diederich W.E., Wong E., Zhu W., Pogmore J.P, Nandy J.P., Satyanarayana M., Jimmidi R.K., Arya P., Leber B., Lin J., Culmsee C., Yi J., and Andrews, D.W., A small molecule inhibitor of both proapoptotic Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection.(2017) Cell Chemical Biology.24(4):493-506.e5. doi: 10.1016/j.chenbiol.2017.03.011.
Read MoreShedding light on apoptosis at subcellular membranes
Andrews, D.W., Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins. Mitochondrial Dynamics and Physiology, Keystone Symposia on Molecular and Cellular Biology. Santa Fe, New Mexico, United States, February 19, 2014.
Read MoreBCL-2 family proteins: changing partners in the dance towards death
Kale J., Osterlund E.J., and Andrews, D.W. BCL-2 family proteins: changing partners in the dance towards death. (2018) Cell Death Differ. 25(1):65-80. doi: 10.1038/cdd.2017.186. Review.
Read MorePhosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance
Kale J., Kutuk O., Costa Brito G., Andrews T., Leber B., Letai A., and Andrews D.W. Phosphorylation switches Bax from promoting to inhibiting apoptosis increasing drug resistance. (2018) EMBO Rep. 19(9):e45235. doi: 10.15252/embr.201745235.
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