Pharmacological Targeting of Executioner Proteins: Controlling Life and Death
Pogmore JP, Uehling D, Andrews DW. Pharmacological Targeting of Executioner Proteins: Controlling Life and Death. J Med Chem. 2021 May 13;64(9):5276-5290. doi: 10.1021/acs.jmedchem.0c02200.
Read MoreAllosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax
Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax. Mol Cell. 2020 Feb 20;77(4):901-912.e9. doi: 10.1016/j.molcel.2019.12.025.
Read MoreRapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning
Mergenthaler P, Hariharan S, Pemberton JM, Lourenco C, Penn LZ, Andrews DW. Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning. PLoS Comput Biol. 2021 Feb 22;17(2):e1008630. doi: 10.1371/journal.pcbi.1008630.
Read MoreNeuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins
Pemberton JM, Pogmore JP, Andrews DW. Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins. Cell Death Differ. 2021 Jan;28(1):108-122. doi: 10.1038/s41418-020-00654-2.
Read MoreBDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models
Vervloessem T, Sasi BK, Xerxa E, Karamanou S, Kale J, La Rovere RM, Chakraborty S, Sneyers F, Vogler M, Economou A, Laurenti L, Andrews DW, Efremov DG, Bultynck G. BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models. Cell Death Dis. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6.
Read MoreHighly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications
Hirmiz N, Tsikouras A, Osterlund EJ, Richards M, Andrews DW, Fang Q. Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications. IEEE Journal of Selected Topics in Quantum Electronics. 2020. doi: 10.1109/JSTQE.2020.2997834.
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