TAMP Project
Homo sapiens Saccharomyces cerevisiae Arabidopsis thaliana Updated Homo sapiens Updated Saccharomyces cerevisiae Updated Arabidopsis thaliana TAMP Application and Manual Tail-anchored membrane proteins (TAMPs) are unusual integral membrane proteins, because they are obliged to target to membranes post-translationally. Although predicted to comprise 3-5% of all transmembrane proteins, only a small number of TAMPs are well characterized. To identify novel putative TAMPs across different species, we used TAMPfinder software to identify 859, 657 and 119 putative TAMPs in human (Homo sapiens),...
Read MoreThe MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Wei Y, Ahlner A, Redel C, Lemak A, Johansson-Åkhe I, Houliston S, Kenney TMG, Tamachi A, Morad V, Duan S, Andrews DW, Wallner B, Sunnerhagen M, Arrowsmith CH, Penn LZ. The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Nucleic Acids Research. 2022 Feb 6. In press.
Read MoreChemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sánchez-Osuna M, Coulombe-Huntington J, Huard C, Mohammed M, Lima-Fernandes E, Thériault B, Halabelian L, Chan M, Joshi D, Drecun L, Yao Z, Pathmanathan S, Wong V, Lyakisheva A, Aboualizadeh F, Niu L, Li F, Kiyota T, Subramanian R, Joseph B, Aman A, Prakesch M, Isaac M, Mamai A, Poda G, Vedadi M, Marcellus R, Uehling D, Leighl N, Sacher A, Samaržija M, Jakopović M, Arrowsmith C, Tyers M, Tsao MS, Andrews D, Al-Awar R, Stagljar I. Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK...
Read MoreBcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis.
Rosa N, Ivanova H, Wagner LE 2nd, Kale J, Lemmens I, Karamanou S, Louros N, Shabardina V, Welkenhuyzen K, La Rovere R, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Mikoshiba K, Economou A, Tavernier J, Andrews DW, Parys J, Yule DI, Bultynck G. Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell Death Differ. 2021 Oct 7. Accepted.
Read MoreMYC protein interactors in gene transcription and cancer
Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. MYC protein interactors in gene transcription and cancer. Nat Rev Cancer. 2021 Jun 29. doi: 10.1038/s41568-021-00367-9. Epub ahead of print.
Read MoreAn amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane
Lv F, Qi F, Zhang Z, Wen M, Piai A, Du L, Zhou L, Yang Y, Wu B, Liu Z, Rosario J, Pogmore JP, Chou JJ, Andrews DW, Jin J, Yang BO. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. EMBO Journal. 2021 Jun 8:e106438. doi: 10.15252/embj.2020106438.
Read More
Find David Andrews Lab Plasmids