Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis.

Rosa N, Ivanova H, Wagner LE 2nd, Kale J, Lemmens I, Karamanou S, Louros N, Shabardina V, Welkenhuyzen K, La Rovere R, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Mikoshiba K, Economou A, Tavernier J, Andrews DW, Parys J, Yule DI, Bultynck G. Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell Death Differ. 2021 Oct 7. Accepted.