Publications

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax. Mol Cell. 2020 Feb 20;77(4):901-912.e9. doi: 10.1016/j.molcel.2019.12.025.

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Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

Mergenthaler P, Hariharan S, Pemberton JM, Lourenco C, Penn LZ, Andrews DW. Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning. PLoS Comput Biol. 2021 Feb 22;17(2):e1008630. doi: 10.1371/journal.pcbi.1008630.

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Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins

Pemberton JM, Pogmore JP, Andrews DW. Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins. Cell Death Differ. 2021 Jan;28(1):108-122. doi: 10.1038/s41418-020-00654-2.

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BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

Vervloessem T, Sasi BK, Xerxa E, Karamanou S, Kale J, La Rovere RM, Chakraborty S, Sneyers F, Vogler M, Economou A, Laurenti L, Andrews DW, Efremov DG, Bultynck G. BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models. Cell Death Dis. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6.

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Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications

Hirmiz N, Tsikouras A, Osterlund EJ, Richards M, Andrews DW, Fang Q. Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications. IEEE Journal of Selected Topics in Quantum Electronics. 2020. doi: 10.1109/JSTQE.2020.2997834.

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The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

Longo J, Smirnov P, Li Z, Branchard E, van Leeuwen JE, Licht JD, Haibe-Kains B, Andrews DW, Keats JJ, Pugh TJ, Trudel S, Penn LZ. The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma. Leukemia. 2021 Mar;35(3):796-808. doi: 10.1038/s41375-020-0962-2.

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