Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Liu Q, Oesterlund EJ, Chi X, Pogmore J, Leber B, Andrews D.W., Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2. (2019). Elife. 8:e37689. doi: 10.7554/eLife.37689.
Read MoreBcl-XL inhibits membrane permeabilization by competing with Bax
Billen L.P., Kokoski C.L., Lovell J.F., Leber, B., and Andrews, D.W., Bcl-XL inhibits membrane permeabilization by competing with Bax. (2008) PLoS Biol 6(6): e147. [Featured in a mini-review in the same issue and in Research Highlights, Nature Immunology, August 2008, 9:837; Faculty 1000 Biology: http://www.f1000biology.com/article/id/1123833/evaluation].
Read MoreDifferences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells
Aranovich, A., Liu, Q., Collins, T.J., Geng F., Dixit S., Leber B., and Andrews, D.W., Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. (2012) Mol Cell., 45:754-63.
Read MoreMechanisms of action of Bcl-2 family proteins
Shamas-Din A., Kale J., Leber B., and Andrews, D.W., Mechanisms of action of Bcl-2 family proteins. (2013) Cold Spring Harbor Perspectives In Biology, 5(4):a008714. (Review)
Read MoreHigh-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells
Oppermann S., Ylanko J., Shi Y., Hariharan S., Oakes C.C., Brauer P.M., Zuniga-Pflucker J.C., Leber B., Spaner D.E., and Andrews, D.W., High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells. (2016) Blood. 128(7):934-947. doi: 10.1182/blood-2015-12-687814.
Read MoreA small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection
Niu X., Brahmbhatt H., Mergenthaler P., Zhang Z., Sang J., Daude M., Ehlert F.G.R., Diederich W.E., Wong E., Zhu W., Pogmore J.P, Nandy J.P., Satyanarayana M., Jimmidi R.K., Arya P., Leber B., Lin J., Culmsee C., Yi J., and Andrews, D.W., A small molecule inhibitor of both proapoptotic Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection.(2017) Cell Chemical Biology.24(4):493-506.e5. doi: 10.1016/j.chenbiol.2017.03.011.
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