TAMP Project
Homo sapiens Saccharomyces cerevisiae Arabidopsis thaliana Updated Homo sapiens Updated Saccharomyces cerevisiae Updated Arabidopsis thaliana TAMP Application and Manual Tail-anchored membrane proteins (TAMPs) are unusual integral membrane proteins, because they are obliged to target to membranes post-translationally. Although predicted to comprise 3-5% of all transmembrane proteins, only a small number of TAMPs are well characterized. To identify novel putative TAMPs across different species, we used TAMPfinder software to identify 859, 657 and 119 putative TAMPs in human (Homo sapiens),...
Read MoreMYC protein interactors in gene transcription and cancer
Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. MYC protein interactors in gene transcription and cancer. Nat Rev Cancer. 2021 Jun 29. doi: 10.1038/s41568-021-00367-9. Epub ahead of print.
Read MoreAn amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane
Lv F, Qi F, Zhang Z, Wen M, Piai A, Du L, Zhou L, Yang Y, Wu B, Liu Z, Rosario J, Pogmore JP, Chou JJ, Andrews DW, Jin J, Yang BO. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. EMBO Journal. 2021 Jun 8:e106438. doi: 10.15252/embj.2020106438.
Read MorePharmacological Targeting of Executioner Proteins: Controlling Life and Death
Pogmore JP, Uehling D, Andrews DW. Pharmacological Targeting of Executioner Proteins: Controlling Life and Death. J Med Chem. 2021 May 13;64(9):5276-5290. doi: 10.1021/acs.jmedchem.0c02200.
Read MoreAllosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax
Bogner C, Kale J, Pogmore J, Chi X, Shamas-Din A, Fradin C, Leber B, Andrews DW. Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax. Mol Cell. 2020 Feb 20;77(4):901-912.e9. doi: 10.1016/j.molcel.2019.12.025.
Read MoreNature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening
Nature Webinar – Understanding cancer drug responses, efficacy and resistance using high-content screening
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